FAQ
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When SPR is 100% of what we do, 100% of our expertise and focus goes into your project unlike generalist CROs where your work competes with dozens of other service lines. Many sophisticated biotech teams prefer working with best-in-class specialists for each technique. The peace of mind from knowing your kinetics data will be clean and defensible is worth coordinating with a dedicated partner. We are also happy to refer you to expert partners in other assay technologies to follow-up on SPR results.
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We operate Cytiva Biacore systems, the gold standard for regulatory submissions and publication-quality data. The Biacore platform is the most widely accepted SPR system globally, and your data will be directly comparable to most internal measurements. You'll never have a collaborator or regulator ask you to re-run on a different platform.
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Our turnaround advantage comes from specialization. We don't waste time figuring out assay conditions we've already optimized hundreds of times, and we don't have scheduling conflicts with other service lines. We're transparent about capacity and will tell you upfront if timeline is a risk. When we say we'll deliver, you can trust it.
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Unusual is our comfort zone. We've successfully run SPR on bifunctional molecules, ADCs, PROTACs, and large protein complexes. Complex molecules require creative assay design, and that's exactly where deep SPR expertise matters. When a client brings us something new, we get excited. It's a chance to solve a puzzle using lessons from thousands of prior experiments.
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Membrane proteins are one of our specialties. We've developed specific approaches through years of focused work, including nanodisc capture, lipid-supported surfaces, and optimized regeneration that preserves membrane protein integrity. We've successfully generated kinetic data for GPCRs and ion channels. Membrane protein SPR isn't impossible; it's just hard, and hard is what we specialize in.
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A complete report should include: detailed methods (surfaces, conditions, regeneration), sensorgrams with fits, kinetic constants with error estimates, assessment of data quality (chi-squared, residuals), and discussion of any anomalies. Raw data files should be available for independent analysis, and any decisions about model selection or data exclusion should be documented and justified.

