Fragment-Based Drug Discovery (FBDD)

• High-throughput fragment library screening
• Hit identification and validation
• Fragment binding kinetics

Ideal for: Early-stage drug discovery programs

Deliverables: Ranked hit lists, KD values, sensorgrams

Hit-to-Lead & Lead Optimization

• Multi-dose response studies
• Structure-activity relationship (SAR) support
• Binding kinetics characterization (ka, kd, KD)
• Residence time analysis

Ideal for: Medicinal chemistry teams

Deliverables: Full kinetic profiles, comparative analysis

Antibody Characterization

• Antigen-antibody affinity determination
• Off-rate ranking from crude samples
• Cross-reactivity and specificity profiling
• Epitope binning
• FcγR and FcRn binding analysis
• Bispecific antibody characterization

Ideal for: Biologics development

Deliverables: Affinity constants, epitope maps, binding profiles

Target Validation & Mode of Action

• Protein-protein interactions
• Competition assays
• Co-binding studies (allosteric vs. active site)
• Stoichiometry determination

Ideal for: Target validation, mechanism studies